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I suppose: Alyx could be remade into a combine against her will, because the alliance has zombie and submission technologies.
And Bryn could personally order that Alyx be converted into an elite combine assassin.
With her help, it was easier for Brin to manipulate Eli, sending her own daughter on a mission against her father, or throw her into a battle against resistance at any time,
which guarantees 100% death. Before that, Alyx - combine could better than others gather the necessary information for reconnaissance and help the alliance forces for a successful offensive.
If a similar alternative scenario were laid in the game, it would only be for it. And there would also be, for example, an opportunity for Freeman to track down Alex - the combine to return it to Eli. And the Vortigaunts with their superpowers could easily return Alex to consciousness.